MASH Explorer is a comprehensive and user-friendly software environment for top-down proteomics, which includes a downloadable software package, MASH Explorer App, as a versatile, comprehensive platform for top-down proteomics with the capability to process data from various vendor formats and incorporate multiple algorithms for deconvolution and database searching. It is developed by an interdisciplinary team consisting of experts in top-down mass spectrometry-based proteomics, computational data science, and bioinformatics/biostatistics.

The software is based on our recent developments of MASH Suite Pro as well as MASH Suite, which can process data from various vendors and can incorporate multiple algorithms for deconvolution and database search.

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Raw File Formats Include:

Thermo (*.raw) data files
Bruker (*.d and*.ascii) data files
*.mzXML data files
*.mgf data files
Waters data files

    Supported Deconvolution Algorithms:

    Ms-Deconv
    TopFD
    eTHRASH
    pParseTD
    ProMex

      Supported Database Search:

      MS-Align+
      TopPIC
      pTOP
      MSPathFinderT