Welcome to Ge Research Group!

The Ge lab at UW-Madison aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies.


Ying Ge, PhD

Professor, Department of Cell and Regenerative Biology
Professor, Department of Chemistry
Director of Mass Spectrometry
Human Proteomics Program
School of Medicine and Public Health
University of Wisconsin-Madison
Biographical Sketch

Faculty trainer, Translational Cardiovascular Science Training Program
Faculty trainer, Chemistry-Biology Interface Training Program
Faculty trainer, UW Graduate Program in Cellular and Molecular Biology
Faculty trainer, UW Graduate Program in Molecular and Cellular Pharmacology
Faculty trainer, UW Graduate Program in Cellular and Molecular Pathology

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    News and Updates

  • July 2019, MASH Explorer software is available to the public. You can download the software using this link. [Link]
  • June 2019, Dr. Bifan Chen and Dr. Yutong Jin have left our research group. Bifan will be joining Genentech and Yutong will be working for Biogen. They will for sure be missed by our lab members! [Photos]
  • June 2019, The Ge Group attended the 2019 ASMS Conference in Atlanta, GA! [Photos]
  • May 2019, The Ge Group celebrated Dr. Bifan Chen's and Dr. Yuton Jin's graduation! Congratulations to you both! [Photos]
  • May 2019, Follow us on Twitter at @Ge_Lab_UW!
  • April 2019, Andreas Kyrvasilis was awarded the sophomore research scholarship. Congratulations!
  • April 2019, Kyle Brown's paper on a photocleavable surfactant for top-down proteomics is published in Nature Methods! [Article] [News Release]
  • April 2019, Bifan received the Gary Parr Memorial Award! Congratulations!
  • April 2019, Abe is awarded the Doban Mentoring Award! Congratulations!
  • April 2019, Morgan received the Eugene and Patricia Kreger Herscher Scholarship, the Henry and Eleanor Firminhac Chemistry Scholarship, and the Margaret McLean Bender Scholarship!
  • Feburary 2019, Trisha Tucholski is awarded the 2019 ASMS (American Society for Mass Spectrometry) Graduate Student Travel Award. Congratulations!
  • January 2019, The Ge Lab celebrated a Holiday Party! [Photos]

Most Recent Publications

  1. Brown, K. A.; Chen, B.; Guardado-Alvarez, T. M.; Lin, Z.; Hwang, L.; Ayaz-Guner, S.; Jin, S.; Ge, Y. A Photocleavable Surfactant for Top-Down Proteomics, Nature Methods. 2019. Article. News Release.
  2. Jin, Y.; Diffee, G. M.; Colman, R. J.; Anderson, R. M.; Ge, Y. Top-down Mass Spectrometry of Sarcomeric Protein Post-translational Modifications from Non-human Primate Skeletal Muscle, J. Am. Soc. Mass Spectrom. 2019. Epub ahead of print. DOI: 10.1007/s13361-019-02139-0 Article
  3. Tucholski, T.; Knott, S.; Chen, B.; Pistono, P.; Lin, Z.; Ge, Y. A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Anal Chem., 2019, 91, 3855-3844. DOI: 10.1021/acs.analchem.8b04082. Article
  4. Liang, Y.; Jin, Y.; Wu, Z.; Tucholski, T.; Brown, K.A.; Zhang, L.; Zhang, Y.; Ge, Y. Bridged Hybrid Monolithic Column Coupled to High-Resolution Mass Spectrometry for Top-down Proteomics, Anal Chem., 2019, 91, 3, 1743-1747. DOI: 10.1021/acs.analchem.8b05817. Article
  5. Gregorich, Z.R.; Patel, J.R.; Cai, W.; Lin, Z.; Heurer, R.; Fitzsimons, D.P.; Moss, R.L.; Ge, Y. Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium, J Gen Physiol., 2019. PII: jgp.201812214. DOI: 10.1085/jgp.201812214. Article
  6. Berry, J.L.; Zhu, W.; Tang, Y.L.; Krishnamurthy, P.; Ge, Y.; Cooke, J.P.; Chen, Y.; Garry, D.J.; Yang, H.T.; Rajasekaran, N.S.; Koch, W.J.; Li, S., Domae, K.; Qin, G.; Cheng, K.; Kamp, T.J.; Ye, L.; Hu, S.; Ogle, B.M.; Rogers, J.M.; Abel, E.D.; Davis, M.E.; Prabhu, S.D.,; Liao, R.; Pu, W.T.; Wang, Y.; Ping, P.; Bursac, N.; Vunjak-Novakovic, G.; Wu, J.C.; Bolli, R.; Menasché, P.; Zhang, J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure, Circ Res., 2019, 124, 1, 161-169. DOI: 10.1161/CIRCRESAHA.118.314216. Article
  7. Lin, Z.; Wei, L.; Cai, W.; Zhu, Y.; Tucholski, T.; Mitchell, S.D.; Guo, W.; Ford, S.P.; Diffee, G.M.; Ge, Y. Simultaneous Quantification of Protein Expression and Modifications by Top-down Targeted Proteomics: A Case of Sarcomeric Subproteome, Mol Cell Proteomics., 2019, 18, 3, 594-605. PII: mcp.TIR118.001086. DOI: 10.1074/mcp.TIR118.00108. Article
  8. Jin, Y.; Lin, Z.; Xu, Q.; Fu, C.; Zhang, Z.; Zhang, Q.; Pritts, W.A.; Ge, Y. Comprehensive characterization of monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry, MAbs., 2019, 11, 1, 106-115. DOI: 10.1080/19420862.2018.1525253. Article

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