y Ying Ge Research Group - UW-Madison


At UW-Madison:


  1. Gao, L.; Gregorich, Z. R.; Zhu, W.; Mattapally, S.; Lou, X.; Borovjagin, A. V.; Walcott, G. P.; Pollard, A. E.; Fast, V. G.; Ge, Y.; Zhang, J. Large cardiac-muscle patches engineered from human induced-pluripotent stem-cell–derived cardiac cells improve recovery from myocardial infarction in swine, Circulation, 2017, Epub ahead of print, DOI:10.1161/CIRCULATIONAHA.117.030785 Article
  2. Chen, B.; Brown, K.A.; Lin, Z.; Ge, Y. Top-down proteomics: ready for prime time? Anal. Chem. 2017 Epub ahead of print, DOI: 10.1021/acs.analchem.7b04747. (Ge, Y. Corresponding author) Article

  3. Wei, L.; Gregorich, Z. R.; Lin, Z.; Cai, W.; Jin, Y.; McKiernan, S. H.; Mcilwain, S.; Aiken, J. M.; Moss, R. L.; Diffee, G. M.; Ge, Y. Novel sarcopenia-related alterations in sarcomeric protein post-translational modifications in skeletal muscles identified by top-down proteomics, Mol. Cell. Proteomics, Epub ahead of print, DOI: 10.1074/mcp.RA117.000124 (Ge, Y. Corresponding author) Article
  4. Hu, C.; Worth, M.; Fan, D.; Li, B.; Li, H.; Lu, L. Zhong, X.; Lin, Z.; Wei, L.; Ge, Y.; Li, L.; Jiang, J. Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase, Nat. Chem. Biol. Epub ahead of print. DOI: 10.1038/nchembio.2494. Article
  5. Rana, A. S. J. B.; Ge, Y.; Strieter, E. R. Ubiquitin chain enrichment middle-down mass spectrometry (ubichem-ms) reveals cell-cycle dependent formation of lys11/lys48 branched ubiquitin chains. J. Proteome Res.. 2017, 16 , 3363-3369. DOI: 10.1021/acs.jproteome.7b00381. Article
  6. Chen, B.; Guo, X.; Tucholski, T.; Lin, Z.; Mcilwain, S.; Ge, Y. The impact of phosphorylation on electron capture dissociation of proteins: a top-down perspective. J. Am. Soc. Mass Spectrom., 2017, 28, 1805–1814. DOI: 10.1007/s13361-017-1710-3 (Ge, Y. Corresponding author) Article

  7. Wu, C.-G., Chen, H., Guo, F., Yadav, V. K., McIlwain, S. J., Rowse, M., Choudhary, A., Lin, Z., Li, Y., Gu, T., Zheng, A., Xu, Q., Lee, W., Resch, E., Johnson, B., Day, J., Ge, Y., Ong, I. M., Burkard, M. E., Ivarsson, Y., Xing, Y. PP2A-B′ holoenzyme substrate recognition, regulation and role in cytokinesis. Cell Disc. 2017, 3, 17027. DOI:10.1038/celldisc.2017.27 Article
  8. Gregorich Z. R.; Cai, W.; Lin, Z.; Chen, A. J.; Peng, Y.; Kohmoto, T.; Ge, Y. Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry. J. Mol. Cell. Cardiol., 2017, 107, 13-21. DOI: 10.1016/j.yjmcc.2017.04.002. (Ge, Y. Corresponding author) Article

  9. Cai, W.; Tucholski, T.; Chen, B.; Alpert, A. J.; McIlwain, S.; Kohmoto, T.; Jin, S.; Ge, Y. Top–down Proteomics of Large Proteins up to 223 kDa Enabled by Serial Size Exclusion Chromatography Strategy. Anal Chem., 2017, 89, 5467-5475. DOI: 10.1021/acs.analchem.7b00380. (Ge, Y. Corresponding author) Article

  10. Jin, Y.; Wei, L.; Cai, W.; Lin, Z.; Wu, Z.; Peng, Y.; Kohmoto, T.; Moss, R. M.; Ge, Y. Complete Characterization of Cardiac Myosin Heavy Chain (223 kDa) Enabled by Size-Exclusion Chromatography and Middle-down Mass Spectrometry. Anal Chem., 2017, 89, 4922-4930. DOI: 10.1021/acs.analchem.7b00113. (Ge, Y. Corresponding author) Article

  11. Chen, B.; Hwang, L.; Ochowicz, W.; Lin, Z.; Guardado-Alvarez, T. M.; Cai, W.; Xiu, L.; Dani, K.; Colah, C.; Jin, S.; Ge, Y. Coupling Functionalized Cobalt Ferrite Nanoparticle Enrichment with Online LC/MS/MS for Top-down Phosphoproteomics. Chem. Sci., 2017, DOI: 10.1039/C6SC05435H. (Ge, Y. Corresponding author) Article

  12. Yang, L; Gregorich Z. R.; Cai, W.; Zhang, P; Young, B; Gu, Y; Zhang, J; Ge, Y. Quantitative Proteomics and Immunohistochemistry Reveal Insights into Cellular and Molecular Processes in the Infarct Border Zone One Month after Myocardial Infarction. J. Proteome Res., 2017, 16, 2101-2112. DOI: 10.1021/acs.jproteome.7b00107. (Ge, Y. Corresponding author) Article

  13. Crowe, S. O.; Rana, A. S.; Deol, K. K.; Ge, Y.; Strieter, E. R. Ubiquitin Chain Enrichment Middle-Down Mass Spectrometry Enables Characterization of Branched Ubiquitin Chains in Cellulo. Anal Chem., 2017, 89, 4428-4434. DOI: 10.1021/acs.analchem.6b03675. Article

  14. 2016

  15. Gregorich, Z. R.; Cai, W.; Jin, Y.; Wei, L.; Chen, A. J.; McKiernane, S. H.; Aiken, J. M.; Moss, R. L.; Diffee, G. M.; Ge, Y. Top-down targeted proteomics reveals decrease in myosin regulatory light chain phosphorylation that contributes to sarcopenic muscle dysfunction, J. Proteome Res., 2016, 15 (8), pp 2706–2716. DOI: 10.1021/acs.jproteome.6b00244. (Ge, Y. Corresponding author) Article

  16. Crowe, S.O.; Pham, G.H.; Ziegler, J.C.; Deol, K.K.; Guenette, R.G.; Ge, Y.; Strieter, E.R. Subunit-specific labeling of ubiquitin chains by using sortase: insights into the selectivity of deubiquitinases. ChemBioChem., 2016, 17(16):1525-31. DOI: 10.1002/cbic.201600276. Article
  17. Cai, W.; Tucholski, T. M.; Gregorich Z. R.; Ge, Y. Top-down proteomics: technology advancements and application to heart diseases. Expert Rev. Proteomics., 2016, 13, 717-730. DOI: 10.1080/14789450.2016.1209414 (Ge, Y. Corresponding author) Article

  18. Jin, Y.; Peng, Y.; Lin, Z.; Chen, Y. C.; Wei, L.; Hacker, T. A.; Larsson, L.; Ge, Y. Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics. J Muscle Res Cell Motil., 2016, 37(1-2):41-52. DOI: 10.1007/s10974-016-9443-7. (Ge, Y. Corresponding author) Article
  19. Hwang, L.; Guardado-Alvarez†, T.; Ayaz-Gunner, S.; Ge, Y.; Jin S. A Family of Photolabile Nitroveratryl-Based Surfactants That Self-Assemble into Photodegradable Supramolecular Structures. Langmuir, 2016, 32 (16): pp 3963–3969. (Ge, Y. Corresponding author) Article

  20. Chen, B.; Peng, Y.; Valeja, S. G.; Xiu, L.; Alpert, A. J.; Ge, Y. Online Hydrophobic Interaction Chromatography-Mass spectrometry for Top-down Proteomics. Anal. Chem. 2016, 88(3):1885-91. (Ge, Y. Corresponding author) Article

  21. Cai, W.; Guner, H.; Gregorich, Z. R.; Chen, A. J.; Ayaz-Guner, S.; Peng, Y.; Valeja, S. G.; Liu, X.; Ge, Y. MASH Suite Pro: A Comprehensive Software Tool for Top-down Proteomics. Mol. Cell. Proteomics. 2016, 15(2):703-14. (Ge, Y. Corresponding author) Article

  22. Yu, D.; Peng, Y.; Ayaz-Guner, S.; Gregorich Z. R.; Ge, Y. Comprehensive characterization of AMP-activated protein kinase catalytic domain by top-down mass spectrometry. J. Am. Soc. Mass Spectrom. 2016, 27(2): 220-232 (Ge, Y. Corresponding author) Article

  23. 2015

  24. Gregorich Z. R.; Peng, Y.; Wolff, J. J.; Guo, W.; Guner, H.; Doop, J.; Hacker, T. A.; Ge, Y. Comprehensive assessment of regional and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry. J. Mol. Cell. Cardiol. 2015, 87, 103-112. (Ge, Y. Corresponding author) Article
  25. Chen, Y.-C.; Ayaz-Guner, S.; Peng, Y.; Lane, M. L.; Locher, M.; Larsson, L.; Kohmoto, T.; Moss, R. L.; Ge, Y. A top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker. Anal Chem. 2015, 87(16): 8399-406. (Ge, Y. Corresponding author) Article

  26. Chang, Y. H.; Ye, L.; Cai, W.; Lee, Y.; Guner, H.; Lee, Y.; Kamp, T. J.; Zhang, J.; Ge, Y. Quantitative Proteomics Reveals Differential Regulation of Protein Expression in Recipient Myocardium after Trilineage Cardiovascular Cell Transplantation. Proteomics. 2015, 15, 2560-2567 DOI: 10.1002/pmic.201500131. (Ge, Y. Corresponding author) Article

  27. Valeja, S. G.; Xiu, L.; Gregorich, Z. R.; Guner, H.; Jin, S.; Ge, Y. Three dimensional liquid chromatography coupling ion exchange chromatography/hydrophobic interaction chromatography/reverse phase chromatography for effective protein separation in top-down proteomics. Anal Chem. 2015, 87(10), 5363-71. (Ge, Y. Corresponding author) Article

  28. Hwang, L.; Ayaz-Guner, S.; Cai, W.; Gregorich Z. R.; Jin, S.; Ge, Y. Specific enrichment of phosphoproteins using functionalized multivalent nanoparticles. J. Am. Chem. Soc., 2015, 87, 5363-5371. (Ge, Y. Corresponding author) Article

  29. Chang, Y.; Gregorich Z. R.; Chen, A. J.; Hwang L.; Guner, H.; Yu, D.; Zhang, J.; Ge, Y. New mass spectrometry-compatible degradable surfactant for tissue proteomics. J. Proteome Res., 2015, 14, 1587-1599. (Ge, Y. Corresponding author) Article

  30. Chen, Y.; Sumandea, M. P.; Larsson, L.; Moss, R. L.; Ge, Y. Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry. J. Muscle Res. Cell Motil., 2015, 36, 168-181. (Ge, Y. Corresponding author) Article
  31. 2014

  32. Ye, L.; Chang, Y. H.; Xiong Q.; Zhang P.; Somasundaram, P.; Lepley M.; Swingen C.; Su, L.; Wendel, J. S.; Guo, J.; Jang, A.; Rosenbush, D.; Zhang, L.; Greder, L.; Dutton, J. R.; Zhang, J.; Kamp, T. J.; Kaufman, D.S.; Ge, Y.; Zhang, J. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. Cell Stem Cell, 2014, 15, 750-761. Article

  33. Peng, Y.; Gregorich Z. R.; Valeja, S. G.; Zhang, H.; Cai, W.; Chen, Y.; Guner, H.; Chen, A. J.; Schwahn, D. J.; Hacker, T. A.; Liu, X.; Ge, Y. Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction. Mol. Cell. Proteomics, 2014, 13, 2752-2764. (Ge, Y. Corresponding author) Article

  34. Ge, Y.; Van Eyk, J. Cardiovascular disease: the leap towards translational and clinical proteomics. Proteomics Clin. Appl., 2014, 8, 473-475. Article
  35. Xiu, L.; Valeja, S. G.; Alpert, A. J.; Jin, S.; Ge, Y. Effective protein separation by coupling hydrophobic interaction and reverse phase chromatography for top-down proteomics. Anal. Chem. 2014, 86, 7899-7906. (Ge, Y. Corresponding author) Article

  36. Valkevich, E. M.; Sanchez, N.; Ge, Y.; Strieter, E. R. Middle-down mass spectrometry enables characterization of branched ubiquitin chains. Biochemistry, 2014, 53, 4979−4989. Article

  37. Peng, Y.; Ayaz-Guner, S.; Yu, D.; Ge, Y. Top-down mass spectrometry of cardiac myofilament proteins in health and disease, Proteomics Clin. Appl. 2014, 8, 554–568. (Ge, Y. Corresponding author) Article
  38. Gregorich Z. R.; Ge, Y. Top-down proteomics in health and disease: challenges and opportunities, Proteomics, 2014, 14, 1195-1210. (Ge, Y. Corresponding author) *This is an invited article for a special issue on “Top-down proteomics”. Article
  39. Gregorich Z. R.; Chang, Y.-W.; Ge, Y. Proteomics in heart failure: top-down or bottom-up? Pflugers Arch. Eur. J. Physiol. 2014, 466, 1199-1209. (Ge, Y. Corresponding author) *This is an invited review for a special issue on “Heart Failure”. Article
  40. Witayavanitkul, N.; Sarkey, J.; Mou, Y. A.; Kuster, D.W.D.; Khairallah, R. J.; Govindan, S.; Chen, X.; Ge, Y.; Rajan, S.; Wieczorek, D. F.; Irving, T.; de Tombe, P. P.; Sadayappan, S. Myocardial infarction-induced N-terminal fragment of cMyBP-C impairs myofilament function in human left ventricular myofibrils, J. Biol. Chem. 2014, 289, 8818-8827 Article
  41. Chen, S.; Zhu, P.; Guo, H.; Wang, Y.; Ma, Y.; Wang, J.; Gao, J.; Chen, J.; Ge, Y.; Zhuang, J.; Li, J. Alpha-1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I, Life Sci., 2014, 98, 75-82. Article
  42. Guner, H.; Close, P.L.; Cai, W.; Zhang, H.; Peng, Y.; Chen, Y.; Gregorich, Z. R. Ge, Y. MASH Suite: A user-friendly and versatile software interface for high-resolution mass spectrometry data interpretation and visualization, J. Am. Soc. Mass Spectrom. 2014, 25, 464-470. (Ge, Y. Corresponding author) Article

  43. 2013

  44. Zhao, D. S.; Gregorich Z. R.; Ge, Y. High throughput screening of disulfide-containing proteins in a complex mixture, Proteomics, 2013, 13, 3256-3260. (Ge, Y. Corresponding author) Article
  45. Peng, Y.; Yu, D.; Gregorich Z., Chen, X.; Beyer, A. M.; Gutterman, D. D.; Ge, Y. In-depth proteomic analysis of human tropomyosin by top-down mass spectrometry, J. Muscle Res. Cell Motil. 2013, 34, 199-210. (Ge, Y. Corresponding author) *This is an invited article for a special edition on “Tropomyosin: form and function”. Article
  46. Miao, J.; Lawrence, M.; Jeffers, V.; Zhao, F.; Parker, D.; Ge, Y.; Sullivan, W. J.; Cui, L. Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development, Mol. Microbiol. 2013, 89, 660-675. Article
  47. Chen, X.; Ge, Y. Ultra-high pressure fast size exclusion chromatography for top-down proteomics, Proteomics, 2013, 13, 2563-2566. (Ge, Y. Corresponding author) Article
  48. Smith LM, Kelleher NL; Consortium for Top Down Proteomics (Linial M, Goodlett D, Langridge-Smith P, Goo YA, Safford G, Bonilla L, Kruppa G, Zubarev R, Rontree J, Chamot-Rooke J, Garavelli J, Heck A, Loo J, Penque D, Hornshaw M, Hendrickson C, Pasa-Tolic L, Borchers C, Chan D, Young N, Agar J, Masselon C, Gross M, McLafferty F, Tsybin Y, Ge Y, Sanders I, Langridge J, Whitelegge J, Marshall A.), Proteoform: a single term describing protein complexity. Nat Methods. 2013, 10, 186-187. Article
  49. Guy, M. J.; Chen, Y.; Clinton, L.; Zhang, H.; Zhang, J.; Dong, X.; Xu, Q.; Ayaz-Guner, S.; Ge, Y. The impact of antibody selection on the detection of cardiac troponin I, Clin. Chim. Acta. 2013, 420, 82-88. (Ge, Y. Corresponding author) *This is an invited article for a special issue on “Mass Spectrometry for Clinical Diagnosis”. Article
  50. Peng, Y.; Chen, X.; Zhang, H.; Xu, Q.; Hacker, T. A.; Ge, Y. Top-down targeted proteomics for deep sequencing of tropomyosin isoforms, J. Proteome Res. 2013, 12, 187-198. (Ge, Y. Corresponding author) Article
  51. 2012

  52. Trang, V. H.; Valkevich, E. M.; Minami, S.; Chen, Y.; Ge, Y.; Strieter, E. R. Nonenzymatic polymerization of ubiquitin: single-step synthesis and isolation of discrete ubiquitin oligomers, Angew. Chem. Int. Ed. 2012, 124, 13262-13265. Article
  53. Yang, C.; Park, A. C.; Davis, N. A,; Russell, J. D.; Kim, B.; Brand, D. D.; Lawrence, M. J.; Ge, Y.; Coon, J. J.; Greenspan, D. S.; Comprehensive mass spectrometric mapping of the hydroxylated amino acid residues of the a1(V) collagen chain, J. Biol. Chem. 2012, 287, 40598-40610 Article
  54. Jia, C.; Hui, L.; Cao, W.; Lietz, C. B.; Jiang, X.; Chen, R.; Catherman, A. D.; Thomas, P. M.; Ge, Y.; Kelleher, N. L.; Li.; L. High-definition de novo sequencing of crustacean hyperglycemic hormone (CHH)-family neuropeptides, Mol. Cell Proteomics, 2012, 11, 1951-64. Article
  55.  Ge, Y.; Moss, R. L. Nitroxyl, redox switches, cardiac myofilaments, and heart failure: A prequel to novel therapeutics? Circ. Res. 2012, 111, 954-956. Article
  56. Peng, Y.; Chen, X.; Sato, T., Rankin, S. A.; Tsuji, R. F.; Ge, Y. Rapid purification and high-resolution top-down mass spectrometric characterization of human salivary α-amylase, Anal. Chem. 2012, 84, 3339-3346. (Ge, Y. Corresponding author) Article
  57.  Oliveira, S.M.; Zhang, Y.H.; Sancho Solís, R.; Isackson, H.; Bellahcene, M.; Yavari, A.; Pinter, K.; Davies, J.D., Ge, Y.; Ashrafian, H.; Walker, J. W.; Carling, D.; Watkins, H.; Casadei, B.; Redwood, C. AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes, Circ. Res., 2012, 110, 1192-1201.
  58. Valkevich, E. M.; Guenette, R. G.; Sanchez, N. A.; Chen, Y.; Ge, Y.; Strieter, E. R. Forging isopeptide bonds using thiol-ene chemistry: site-specific coupling of ubiquitin molecules for studying the activity of isopeptidases, J. Am. Chem. Soc. 2012, 134, 6916-6919.
  59. Dong, X.; Sumandea, C. A.; Chen, Y.; Garcia-Cazarin, M. L.; Zhang, J.; Balke, C. M.; Sumandea, M. P.; Ge, Y. Augmented phosphorylation of cardiac troponin I in hypertensive heart failure, J. Biol. Chem. 2012, 287, 848-857. (Ge, Y. Corresponding author)
  60.  Du, J.; Teng, R. J.; Lawrence M.; Guan, T.; Ge, Y.; Shi, Y. The protein partners of GTP cyclohydrolase I (GCH1) in rat organs, Plos One, 2012, 7, e33991.
  61.  Wang, Y.; Pinto, J. R.; Sancho Solis, R.; Liang, J.; Diaz-Perez, Z.; Harada, K.; Ge, Y.; Walker, J. W. Potter, J. D. The generation and functional characterization of knock in mice harboring the cardiac Troponin I-R21C mutation associated with hypertrophic cardiomyopathy, J. Biol. Chem. 2012, 287, 2156-2167.
  62. 2011

  63. Zhang, H.; Ge, Y. Comprehensive analysis of protein modifications by top-down mass spectrometry, Circ. Cardiovasc. Genet. 2011, 4, 711. *This is an invited review for “Integrating proteomics into cardiovascular disease – an educational review series”. (Ge, Y. Corresponding author)
  64. Zhang, J.; Guy, J. M.; Norman, H. A.; Chen, Y.; Dong, X.; Wang, S.; Kohmoto, T.; Young, K. H.; Moss, R. L.; Ge, Y. Top-Down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure, J. Proteome Res. 2011, 10, 4054-4065. (Ge, Y. Corresponding author)
  65. Zhang, J.; Zhang, H.; Ayaz-Guner, S.; Dong, X.; Xu, Q.; Guner, H.; Ge, Y. Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T, Biochemistry, 2011, 50, 6081-6092. (Ge, Y. Corresponding author)
  66. Sancho Solis, R.; 41. Guy, M. J.; Chen, Y.; Clinton, L.; Zhang, H.; Zhang, J.; Dong, X.; Xu, Q.; Ayaz-Guner, S.; Ge, Y. The impact of antibody selection on the detection of cardiac troponin I, Clin. Chim. Acta. Accepted. *This is an invited article. (Ge, Y. Corresponding author)
  67. Kuhn, P.; Chumanov, R.; Wang, Y.; Ge, Y.; Burgess, R. R.; Xu, W. Automethylation of CARM1 allows coupling of transcription and mRNA splicing, Nucl. Acids Res. 2011, 39, 2717-2726.
  68. Xu, F.; Xu, Q.; Dong, X.; Guy, M.; Guner, H.; Hacker, T. A.; Ge, Y. Top-down high-resolution electron capture dissociation mass spectrometry for comprehensive characterization of post-translational modifications in rhesus monkey cardiac troponin I, Int. J. Mass Spectrom. 2011, 305, 95-102. *This is an invited article. (Ge, Y. Corresponding author)
  69. 2010

  70. Nelson, C. A.; Szezech, J. R.; Dooley, C. J.; Xu, Q.; Lawrence, M. J.; Zhu, R.; Jin, S.; Ge, Y. Effective enrichment and mass spectrometry analysis of phosphopeptides using mesoporous metal oxide nanomaterials, Anal. Chem. 2010, 82, 7193-7201. (Ge, Y. Corresponding author)
  71. Zhang, J.; Dong, X.; Hacker, T. A.; Ge, Y. Deciphering modifications in swine cardiac troponin I by Top-down high-resolution tandem mass spectrometry, J. Am. Soc. Mass. Spectrom. 2010, 21, 940-948. (Ge, Y. Corresponding author) * This is an invited article featured on the cover of the journal.
  72. 2009

  73. Ayaz-Guner, S.; Zhang, J.; Li, L.; Walker, J. W.; Ge, Y. In vivo phosphorylation site mapping in mouse cardiac troponin I by high resolution top-down electron capture dissociation mass spectrometry: Ser22/23 are the only sites basally phosphorylated, Biochemistry, 2009, 48, 8161-8170. (Ge, Y. Corresponding author)
  74. Ge, Y.; Rybakova, I.; Xu, Q.; Moss, R. L. Top-down high resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state, Proc. Natl. Acad. Sci. U. S. A. 2009,106, 12658-12663. (Ge, Y. Corresponding author) *This article is a PNAS Direct Submission (Track II).
  75. Kuhn, P.; Xu, Q.; Cline, E.; Zhang, D.; Ge, Y.; Xu, W. Delineating Anopheles gambiae coactivator associated arginine methyltransferase 1 (AgCARM1) by top-down high resolution tandem mass spectrometry, Protein Sci. 2009, 18, 1272-1280. (Ge, Y. Corresponding author)
  76. Du, J.; Wei, N; Xu, H.; Ge, Y.; Vasquez-Vivar, J.; Guan, T.; Oldham, K. T.; Pritchard, K. A.; Shi, Y. Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I, Arterioscler. Thromb. Vasc. Biol. 2009, 29, 2161-2168.
  77. Nelson, C. A.; Szczech, J. R.; Xu, Q.; Jin, S.; Ge, Y. Mesoporous Zirconium oxide nanomaterials effectively enrich phosphopeptides for mass spectrometry-based phosphoproteomics, Chem. Commun. 2009, 6607-6609. (Ge, Y. Corresponding author)
  78. Liu, L.; Hou, J.; Du, J.; Chumanov, R. S.; Xu, Q.; Ge, Y.; Johnson, J.A.; Murphy, R.M. Differential modification of Cys10 alters transthyretin’s effect on beta-amyloid aggregation and toxicity, Protein Eng. Des. Sel. 2009, 1–10.
  79. Ma, M.; Chen, R.; Ge, Y.; He, H; Marshall, A. G.; Li, L. Combining bottom-up and top-down mass spectrometric strategies for de novo sequencing of the Crustacean hyperglycemic hormone (CHH) from Cancer borealis, Anal. Chem. 2009, 81, 240-247.
  80. 2008

  81. Sancho Solis, R.; Ge, Y.; Walker, J. W. Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometry, J. Muscle Res. Cell Motil. 2008, 29, 203-212.
  82. Zabrouskov, V.; Ge, Y.; Schwartz, J.; Walker, J. W. Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometry, Mol. Cell. Proteomics 2008, 7, 1838-1849. (Ge, Y. Corresponding author)

Prior to UW-Madison:

  1. Colabroy, K. L.; Zhai, H. L.; Li, T. F.; Ge, Y.; Zhang, Y.; Liu, A. M.; Ealick, S. E.; McLafferty, F. W.; Begley, T. P., The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry 2005, 44, 7623-7631.
  2. Xiang, J.; Ipek, M.; Suri, V.; Massefski, W.; Pan, N.; Ge, Y.; Tam, M.; Xing, Y.; Tobin, J.; Xu, X.; Tam, S. Synthesis and biological evaluation of sulfonamidooxazoles and b-keto sulfones: selective inhibitors of 11b–hydroxyster oid dehydrogenase type I, Bioorg. Med. Chem. Lett. 2005, 15, 2865-2869.
  3. Ge, Y.; Lawhorn, B. G.; ElNaggar, M.; Sze, S. K.; Begley, T. P.; McLafferty, F. W. Detection of four oxidation sites in viral prolyl-4-hydroxylase by top-down mass spectrometry, Protein Sci. 2003, 12, 2320-2326.
  4. Ge, Y.; ElNaggar, M.; Sze, N.; Oh, H.; Begley, T. P.; McLafferty, F. W.; Boshoff, H.; Barry, C. B. Top down characterization of secreted proteins from Mycobacterium tuberculosis by electron capture dissociation mass spectrometry. J. Am. Soc. Mass Spectrom. 2003, 14, 253-261.
  5. Sze, S. K.; Ge, Y.; Oh, H.; McLafferty, F. W. Plasma electron capture dissociation for the characterization of large proteins by top down mass spectrometry Anal. Chem. 2003, 75, 1599-1603.
  6. Oh, H.; Bruker, K.; Sze, S. K.; Ge, Y.; McLafferty, F. W. Secondary and tertiary structure of gaseous ions characterized by electron capture dissociation mass spectrometry and photofragment spectroscopy, Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 15863-15868.
  7. Sze, S. K.; Ge, Y.; Oh, H.; McLafferty, F. W. Top down mass spectrometry of a 29 kDa protein for characterization of any posttranslational modification to within one residue, Proc. Natl. Acad. Sci. U. S. A. 2002, 99, 1774-1779.
  8. Ge, Y.; Lawhorn, B. G.; ElNaggar, M.; Strauss, E.; Park, J-H.; Begley, T. P.; McLafferty, F. W. Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry, J. Am. Chem. Soc. 2002, 124, 672-678
  9. Xi, J.; Ge, Y.; Kinsland, C. L.; McLafferty, F. W.; Begley, T. P. Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex, Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 8513-8518.
  10. Ge, Y.; Horn, D. M.; McLafferty, F. W. Blackbody infrared radiative dissociation of larger (42 kDa) multiply charged proteins, Int. J. Mass Spectrom. 2001, 210/211, 203-214.
  11. McLafferty, F. W.; Horn, D. M.; Ge, Y..; Cerda, B.; Fridriksson, E.; Breuker, K. New frontiers in molecular mass spectrometry, Adv. Mass Spectrom. 2001, 67, 167-173.
  12. McLafferty, F. W.; Horn, D. M.; Breuker, K.; Ge, Y.; Cerda, B., A. Electron capture dissociation of gaseous multiply charged ions by Fourier-transform ion cyclotron resonance, J. Am. Soc. Mass Spectrom. 2001, 12, 245-249.
  13. Strauss, E.; Kinsland, C.; Ge, Y.; McLafferty, F. W.; Begley, T. P. Phosphopantothenoylcysteine synthetase from Escherichia coli: Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. J. Biol. Chem. 2001, 276, 13513-13516.
  14. Horn, D. M.; Ge, Y.; McLafferty, F. W. Activated ion electron capture dissociation for mass spectral sequencing for larger (42 kDa) proteins, Anal. Chem. 2000, 72, 4778-4784.